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Atherton JC - Homeostatic and excretory functions of the kidney depend on blood flow (?25% cardiac output) and glomerular ultrafiltration (?20% renal plasma flow). Clearance measurements are used to assess renal plasma flow (PAH), glomerular filtration rate (creatinine, inulin), filtration fraction (GFR/RPF), net reabsorption or secretion, and proximal and distal nephron function (lithium, free-water) but all have their limitations.

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