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Severe Bone Marrow Failure Due to Valganciclovir Overdose After Renal Transplantation From Cadaveric Donors: Four Consecutive Cases
Transplantation Proceedings, 07/01/09
Ar MC et al. - Valganciclovir is an l-valyl ester pro-drug of ganciclovir that was initially used to treat cytomegalovirus (CMV)–associated retinitis in patients with human immunodeficiency virus. Currently, it is also indicated for the prevention of CMV disease in solid-organ transplantation. This report demonstrates the in vivo pharmacodynamics of valganciclovir overdose in terms of hematotoxicity in the setting of renal impairment. Valganciclovir, as its derivative ganciclovir, should be used cautiously in patients with renal impairment.
Today in Pharmacology/kinetics...keeping you current
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Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis
Kidney International, 11/05/09
A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
New England Journal of Medicine, 11/20/09
Upfront, randomized, phase II trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma
Cancer, 11/03/09
Today in Transplantation...keeping you current
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Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients
Rheumatology International, 11/04/09
Tubular Toxicity in Sirolimus- and Cyclosporine-Based Transplant Immunosuppression Strategies: An Ancillary Study From a Randomized Controlled Trial
American Journal of Kidney Diseases, 11/19/09
Hyperuricemia Is a Mediator of Endothelial Dysfunction and Inflammation in Renal Allograft Recipients
Transplantation Proceedings, 10/30/09
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