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Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma
Journal of Cancer Research & Clinical Oncology, 06/24/09

Schrader AJ et al. - In a study to assess whether different body mass index (BMI) levels at the time of surgery had an effect on long-term prognosis of renal cell carcinoma (RCC) pts, being overweight was identified as an independent prognostic marker of improved tumor-specific survival in pts with organ-confined RCC.

• 771 pts, with complete information about their BMI, who had undergone renal surgery for RCC were evaluated.
• Mean follow-up was 5.48 yrs.

• Underweight, normal weight, pre-obesity, and obesity were diagnosed in 4 (0.5%), 239 (31%), 356 (46.2%), and 172 (22.3%) RCC pts, respectively.
• Overweight (BMI >25) was significantly associated with younger age and positive nodal status, but not with tumor stage, grade, visceral metastasis, gender, histological subtype, or tumor-related symptoms.
• Overweight pts had a significantly lower risk of cancer-related death; their median 5-yr tumor-specific survival rate was 80% vs 72% for pts with a BMI <25.
• Subgroup analysis revealed that the positive association between overweight and survival was even more pronounced in organ-confined RCC, but no correlation was observed in advanced disease.

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