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See Latest ArticlesAssociations between plasma homocysteine levels, aortic stiffness and wave reflection in patients with arterial hypertension, isolated office hypertension and normotensive controls
Journal of Human Hypertension, 06/19/09
Vyssoulis G et al. – Findings support an independent relationship between circulating homocysteine levels, aortic compliance, and wave reflection.
Methods- Study to evaluate any possible association of homocysteine with arterial stiffness indices in pts with essential arterial hypertension (AH), isolated office hypertension (IOH), and normotensive controls
- Final cohort: 231 normotensives (NTs, 119 men), 480 pts with IOH (196 men) and 1188 pts with essential AH (713 men)
- Screen of all pts for plasma homocysteine levels and lipidaemic profile
- Aortic compliance and wave reflection assessment by carotid-femoral pulse wave velocity (PWVc-f) and aortic augmentation index corrected for heart rate (AIx)
- In total population, stepwise multiple linear regression analysis showed that homocysteine levels remained a significant determinant of PWV independent of traditional factors affecting arterial stiffness and wave reflection
- On separate study of 3 groups, homocysteine levels remained an independent determinant of PWFc-f in all groups
- Homocysteine levels remained an independent determinant of AIx only in IOH and AH but not in NT group
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