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See Latest ArticlesChromogranin A Regulates Renal Function by Triggering Weibel–Palade Body Exocytosis
Journal of the American Society of Nephrology, 06/12/09
Chen Y et al. - \Plasma CHGA correlated positively with endothelin-1 and negatively with GFR. GFR was highly heritable in twin pairs, and common promoter haplotypes of CHGA predicted GFR. In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function.
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