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Tossavainen PH et al. - Late complications in type-1 diabetes are almost always subclinical during childhood and adolescence, and advanced vascular complications are rarely seen. Microalbuminuria may appear as the first sign of microvascular complications, and although it may be intermittent or transient in most young patients, screening is important in clinical diabetes care since microalbuminuria is also a strong risk marker for early cardiovascular morbidity.

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