Nephrology Medical News about Uric acid

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Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients
Nephrology Dialysis Transplantation, 06/08/09

Park JT et al. - Study concludes that hyperuricaemia is common among peritoneal dialysis (PD) patients and is significantly associated with the rate of decline of residual renal function (RRF).

Methods

Study was conducted to investigate:
- the prevalence of hyperuricaemia and
- the relationship between UA and RRF in PD pts
134 PD pts who started dialysis between Jan 2000 and Dec 2005
Timed urine collections were performed within 1 month of PD commencement and at 6-mo intervals thereafter
The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient
Biochemical and clinical data at the time of initial urine collection were considered as baseline

Results

At baseline, 32.8% of the PD pts had hyperuricaemia; majority of them were diabetic
Hypertensive pts had a higher UA level vs normotensive pts
The overall reduction rate of RRF in hyperuricaemic pts was higher vs normouricaemic group
Hyperuricaemia and history of DM showed a negative correlation with the reduction rate of RRF after adjusting for:
- demographic data, comorbid conditions,
- body mass index, baseline RRF and medications

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