Nephrology Medical News about Hyponatremia

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Hyponatremia associated with large-bone fracture in elderly patients
International Urology and Nephrology, 06/01/09

Sandhu HS et al. - The study objective was to determine the incidence of hyponatremia in patients who experienced a substantial skeletal fracture (hip/pelvis/femur). The incidence of hyponatremia in patients with fractures was more than double that of nonfracture patients. Of fracture patients with hyponatremia, 24.2% were taking antidepressants, while none were taking these medications in the nonfracture group. Attention regarding careful follow-up of serum sodium levels in elderly patients seems appropriate.

Exclusive Author Commentary
Michael F. Michelis, 06/02/09

The observation is important and is similar to the findings noted in a study by FG Kengne et al published last year in Q J Med (2008);101:583-588. It seems clear that there is some association between hyponatremia and fractures in older patients. Also, the use of SSRIs would seem to place patients in a higher risk category.

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