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The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis
Journal of the American Society of Nephrology, 05/22/09
Renkema KY et al. - The activation of Ca2+-sensing receptor by increased luminal Ca2+ leads to urinary acidification and polyuria. These beneficial adaptations facilitate the excretion of large amounts of soluble Ca2+, which is crucial to prevent the formation of kidney stones.
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