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See Latest ArticlesRegulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species
Nephrology Dialysis Transplantation, 05/11/09
Van den Hoven MJ et al. - Treatment with lisinopril, spironolactone or their combination significantly blunted the increased glomerular heparanase expression and restored the decreased HS expression in the GBM. In vivo and in vitro results show that not only AngII and ROS, but also aldosterone is involved in the regulation of glomerular heparanase expression.
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