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TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho and myosin light chain kinase dependent mechanism
American Journal of Physiology: Renal Physiology, 05/15/09
Wu X et al. - Caspase activation influences NF-kB signaling via its affect on cytoskeletal changes occurring through RhoA and MLCK pathways. These cell culture experiments support a role for caspase activation in TNF-induced inflammation in the renal endothelium, a key event in LPS-induced AKI.
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