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Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose stimulated glomerular cells and type 2 diabetic glomeruli
Nephrology Dialysis Transplantation, 04/21/09
Xu ZG et al. - The results indicate that AT1 expression is enhanced, at least in part, by 12-LO in the type 2 diabetic glomeruli, and 12-LO inhibition can ameliorate DN progression through downregulation of AT1 expression.
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