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Gava E et al. - The data indicate that in proximal tubular cells, binding of Ang-(1–7) to the receptor Mas stimulates SHP-1, associated with the inhibition of glucose-stimulated p38 MAPK. Ang-(1–7) selectively inhibits glucose-stimulated protein synthesis and TGF-[beta1. In diabetic nephropathy, Ang-(1–7) may partly counteract the profibrotic effects of high glucose.


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