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Wilm's tumor arising in a child with X-linked nephrogenic diabetes insipidus
Pediatric Nephrology, 03/23/09
El-Kares R et al. - The WT1 deletion was not present in leukocyte DNA from the patient or his mother. The authors also noted strong [beta]-catenin (CTNNB1) expression in the tumor cells and identified a heterozygote missense Ser45Cys mutation of exon 3 of CTNNB1. However, the mutation was absent both in the constitutional DNA of the patient and his mother. The concurrence of WT and NDI has not been previously reported and may be unrelated. Nevertheless, this case nicely illustrates the sequence of events leading to sporadic Wilm's tumor.
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