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Regulatory Effect of Parathyroid Hormone on sRANKL-Osteoprotegerin in Hemodialysis Patients With Renal Bone Disease
Therapeutic Apheresis and Dialysis, 03/12/09
Doumouchtsis K et al. - The observation that PTH favors RANKL and inhibits OPG production was only demonstrated in the serum of hemodialysis patients in a low turnover state. The positive correlation between serum OPG and iPTH in normal or high turnover rates implies a homeostatic mechanism to limit bone resorption, probably associated with skeletal resistance to PTH.
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