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Potential Role of Purinergic Signaling in Lithium-induced Nephrogenic Diabetes Insipidus
American Journal of Physiology: Renal Physiology, 02/27/09
Zhang Y et al. - The data indicate that in Li-induced NDI: purinergic signaling in the mCD is sensitized with increased production of PGE2; and P2Y2 and/or P2Y4 receptors may be involved in the enhanced purinergic signaling. The study also reveals the potential beneficial effects of P2Y receptor antagonists in the treatment and/or prevention of Li-induced NDI.
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