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See Latest ArticlesRenin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease
Translational Research, The Journal of Laboratory and Clinical Medicine, 02/16/09
Nistala R et al. - Free radicals such as reactive oxygen species (ROS) are necessary in normal physiologic processes, which include the development of nephrons, erythropoeisis, and tubular sodium transport. Both the blockade of the RAAS and the oxidative stress produce salutary effects on hypertension and glomerular filtration barrier injury. Thus, the focus of current research is on understanding the pathophysiology of chronic kidney disease in the context of an increased RAAS and unbalanced redox mechanisms.
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