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See Latest ArticlesDesign of Combination Angiotensin Receptor Blocker and Angiotensin-Converting Enzyme Inhibitor for Treatment of Diabetic Nephropathy (VA NEPHRON-D)
Clinical Journal of the American Society of Nephrology, 02/23/09
Fried LF et al. - The primary endpoints are time to reduction in estimated GFR (eGFR) of > 50%; reduction in eGFR of 30 ml/min/1.73 m2 (if baseline 60 ml/min/1.73 m2); progression to ESRD (need for dialysis, renal transplant, or eGFR < 15 ml/min/1.73 m2); or death. The secondary endpoint is time to change in eGFR or ESRD. Tertiary endpoints are cardiovascular events, slope of change in eGFR, and change in albuminuria at 1 yr. Specific safety endpoints are serious hyperkalemia (potassium > 6 mEq/L, requiring admission, emergency room visit, or dialysis), all-cause mortality, and other serious adverse events.
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