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See Latest ArticlesLymphovascular invasion predicts poor outcome of urothelial carcinoma of renal pelvis after nephroureterectomy
BJU International, 01/28/09
Chung SD et al. - Data suggest that ipsilateral adrenalectomy is not necessary during radical nephroureterectomy (NU) for treating pts with renal pelvic urothelial carcinoma (UCs). lymphovascular invasion (LVI) appears to be a better prognostic factor for predicting poor outcome than pT stage or tumour grade when using the current tumour-nodes-metastases stage.
Methods- Aim was to evaluate the significance of (LVI) to predict cancer-specific survival (CSS) in pts with renal pelvic urothelial carcinoma (UC)
- 76 pts (38 men, 38 women, mean age of 66 yrs); treated by NU
- Inclusion criteria: nonmetastatic renal pelvic UC with no previous history of bladder cancer, concomitant ureteric lesion, or neoadjuvant chemotherapy
- Age, gender, adrenalectomized or not, pathological T stage, grade, and LVI were examined as risk factors
- Median f/u: 48 mo
- At f/u 10.5% cancer-related deaths were censored; 85.9% were alive and disease-free
- LVI was the only significant predictor of CSS in the univariate and multivariate analyses
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