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Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease
American Journal of Nephrology, 12/10/08
Park JY et al. - Data in this study provide a mechanistic explanation of how roscovitine is effective in PKD, and suggest that further study of this agent should focus on assessment of dose response. The discovery of senescence induced by a PKD effective drug suggests a new area of therapeutic investigation in this disease.
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