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Cyclic AMP-dependent Chloride Secretion Mediates Tubule Enlargement and Cyst Formation by Cultured Mammalian Collecting Duct Cells
American Journal of Physiology: Renal Physiology, 12/09/08
Montesano R et al. - The results further support the notion that cAMP signaling plays a key role in renal cyst formation, at least in part by promoting chloride-driven fluid secretion. This new in vitro model of tubule-to-cyst conversion affords a unique opportunity for investigating the molecular mechanisms that govern the architecture of epithelial tubes, as well as for dissecting the pathophysiological processes underlying cystic kidney diseases.
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