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Angiotensin-(1-7) Activates Growth Stimulatory Pathways in Human Mesangial Cells
American Journal of Physiology: Renal Physiology, 12/09/08
Zimpelmann J et al. - The data indicate that Ang-(1-7) activates MAPK phosphorylation via binding to a specific receptor in human mesangial cells. Stimulation of p38 MAPK phosphorylation by Ang-(1-7) leads to release of arachidonic acid and production of TGF-[beta]1 and extracellular matrix proteins. Ang-(1-7) exerts growth-stimulatory effects in human mesangial cells.
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