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The uraemic toxin phenylacetic acid impairs macrophage function
Nephrology Dialysis Transplantation, 10/23/08
Schmidt S et al. - The present findings show that the uraemic toxin PAA has inhibitory effects on macrophage-killing function, which are mediated by inhibitory effects on transcriptional iNOS regulation. iNOS inhibition by PAA might affect immunoregulatory processes and could play a role in aggravation of immunodeficiency of patients with end-stage renal disease.
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