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See Latest ArticlesPeople with type 1 diabetes using short acting analogue insulins are less dehydrated than those with using human soluble insulin prior to onset of diabetic ketoacidosis
Medical Hypotheses, 10/10/08
Dhatariya K - Diabetic ketoacidosis (DKA) is associated with disturbances of acid base, fluid balance and electrolytes. The new rapid acting analogue insulins have durations of action of between 4 and 6 h. Thus the individual would become absolutely insulin deficient relatively quicker than with human soluble insulin. In this circumstance, the blood glucose would not have time to rise as high as with human soluble insulin deficiency before significant ketosis develops, thus leading to a lesser degree of dehydration. New rapid acting insulin analogues are becoming more widely used. This suggests that the volumes needed to replace those lost prior to the onset of significant DKA may be lower.
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