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Efthimiou I et al. - Although Actinomyces species appear to be susceptible to a wide range of beta-lactam agents which, combined with beta-lactamase inhibitors are regarded as agents of first choice, it is well known that infected simple SRCs are highly resistant to antimicrobial chemotherapy due to poor antibiotic penetration. Therefore, it is unknown whether in the case high doses of penicillin alone could have been curative considering the septic status of the patient and the pharmacokinetic properties of beta-lactam agents in simple SRCs.

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