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See Latest ArticlesA mathematical model of distal nephron acidification: diuretic effects
American Journal of Physiology: Renal Physiology, 08/27/08
Weinstein AM - Inclusion of CNT now reproduces the observed distal acidification defect found with ENaC block, so that this action of amiloride appears to be sufficient to produce "voltage-dependent" distal renal tubular acidosis. The effect of furosemide to enhance distal urinary acidification is not reproduced by the model without major up-regulation of CNT alpha cell transport, perhaps as a result of increased luminal flow.
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