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See Latest ArticlesPhysiologic regulation of the epithelial sodium channel by phosphatidylinositides
Current Opinion in Nephrology and Hypertension, 08/12/08
Pochynyuk O et al. - PIP3 sits at a critical bifurcation in the aldosterone-signaling cascade, increasing ENaC open probability and number. PIP3-effectors mediate increases in ENaC number by suppressing channel retrieval. PIP3 binds ENaC, at a site distinct from that important to PIP2 regulation, to modulate directly open probability. Phosphoinositides play key roles in physiologic control of ENaC and perhaps dysregulation plays a role in disease associated with abnormal renal sodium handling.
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