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See Latest ArticlesThe uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients
Nephrology Dialysis Transplantation, 08/01/08
Cohen G et al. - Baseline [Ca2+]i was increased in PMNLs obtained from HD patients before dialysis but reversed after dialysis. The PHA effects were not mediated via [Ca2+]i. The chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) induced a [Ca2+]i increase and reduced PMNL survival. Extracellular Ca2+ did not affect CPA- and fMLP-induced apoptosis. PHA, without affecting [Ca2+]i, attenuates apoptosis of healthy but not of uraemic PMNLs. CPA and fMLP enhance PMNL apoptosis independently of Ca2+ influx.
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