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Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy
Nephrology Dialysis Transplantation, 07/29/08

Pozdzik AA et al. - An early and massive interstitial inflammation characterized by activated monocytes/macrophages and cytotoxic CD8+CD103+ T lymphocytes is demonstrated for the first time during the progression of experimental AAN. The involvement in an interstitial fibrosis onset of active TGF-(beta) is highly suggested, at least via the psmad2/3 intracellular signalling pathway.

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