Kluger HM et al. - Recent development of antiangiogenic therapy for renal cell carcinoma (RCC) has significantly improved the treatment of these often refractory tumors. Tumor cell expression of VEGF-R1 and -R2 was strongly and inversely correlated with vessel area. Unsupervised hierarchical clustering classified tumors by coordinated expression of VEGF and VEGF-Rs. The distribution of clear cell and papillary tumors was not significantly different between clusters.
