Wagener N et al. – The enhancer of zeste homolog 2 (EZH2) is overexpressed in renal cell carcinoma (RCC); this gene plays a role for both proliferation and apoptosis resistance of RCC cells; thus targeted inhibition of EZH2 may be a novel strategy to improve therapeutic response of RCC Methods
Study of EZH2 expression in primary RCC specimens and in nontumorous tissue samples from adult kidney
Results
EZH2 transcripts detectable in all RCC specimens
Expression levels were significantly higher in tumor tissue than in samples from normal adult kidney
Inhibition of endogenous EZH2 expression in RCC cell lines by RNA interference (RNAi) led to reduced proliferation and increased apoptosis in RCC cells
