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Article Summary
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Merseburger AS et al. – Loss of galectin-3 expression is involved in renal carcinogenesis Methods- Study of galectin-3 expression and prognostic significance in clear cell renal carcinoma
- Immunohistochemical analysis of expression of galectin-3 in 149 clear cell renal carcinomas
- Levels correlated to established clinical parameters: nuclear grade, pathologic stage, lymph node, distant metastasis, pt survival
Results- In normal kidney tissue, galectin-3 expression was uniform in tubular epithelial cells
- Decreased antigen expression levels significantly associated with higher T-stages and unfavorable long-term prognosis
- Association of tumor-specific death with decreased galectin-3 expression on univariate but not multivariate analysis
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