nephrologylinx Medical News about hemodialysis graft occlusion; locally delivered human plasmin

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hemodialysis graft occlusion; locally delivered human plasmin

Article Summary

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A first-in-human phase I trial of locally delivered human plasmin for hemodialysis graft occlusion
Journal of Thrombosis and Haemostasis, 06/24/08

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Free Abstract

Shlansky-Goldberg RD et al. - This first phase I study of Plasmin (Human) TAL 05-00018, infused into thrombosed HD grafts, documents safety at dosages of 1-24 mg and an effective thrombolytic dosage of 24 mg. The results establish a foundation for further clinical study of catheter-based plasmin administration in thrombotic disorders.

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