nephrologylinx Medical News about kidneys; nucleic acid binding Toll-like receptors

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kidneys; nucleic acid binding Toll-like receptors

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Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study
Lupus, 06/11/08

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Ciferska H et al. - Kidneys have a capacity to bind nucleic acids. TLR stimulation leads to the production of tumour necrosis factor-alpha and other pro-inflammatory cytokines and to up-regulation of co-stimulatory molecules necessary for the adaptive immune response. This makes renal tissues a potential target for inflammatory and immune responses in autoimmune disease and in the reaction for the foreign tissue.

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