nephrologylinx Medical News about AT-1 Blockade During Lactation

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Article Summary

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AT-1 Blockade During Lactation As A Model Of Chronic Nephropathy: Mechanisms Of Renal Injury
American Journal of Physiology: Renal Physiology, 04/11/08

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Free Abstract

Machado FG et al. - Oral losartan during lactation can be used as a simple and easily reproducible model of chronic kidney disease in adult life, associated with low mortality and no arterial hypertension until advanced stages. The mechanisms involved in the progression of renal injury in this model include glomerular hypertension, glomerular hypertrophy, podocyte injury and interstitial inflammation.

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