There is a choice for immunosuppressive drug nephrotoxicity: is it time to change Stallone G et al. - The central issue in organ transplantation remains suppression of allograft rejection. Thus, development of immunosuppressive drugs is the key to successful allograft function. To obtain significant long-term improvement in renal allograft outcomes, it may be necessary to adopt new immunosuppressive regimens that rely less on CNIs. [more...]