Renin, prorenin and the kidney: a new chapter in an old saga
Ichihara A et al. - The binding of prorenin to the (pro)renin receptor triggers 2 major pathways: a nonproteolytic conformational change in prorenin to its active form (angiotensin II-dependent pathway) and an intracellular pathway via the (pro)renin receptor itself (angiotensin II-independent pathway). In diabetic animals, an increased plasma prorenin level not only causes the generation of angiotensin II via the angiotensin II-dependent pathway, it also stimulates the (pro)renin receptor’s own intracellular signaling pathway in a manner that is independent of the generated angiotensin II. [more...]
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