Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma
Hu J et al. - In a trial to examine the association between dietary intake of vitamin C, E, and carotenoids and risk of renal cell carcinoma (RCC), the findings provide evidence that a diet rich in β-carotene and lutein/zeaxanthin may play a role in RCC prevention. Methods- Mailed questionnaires were completed by 1138 incident, histologically confirmed cases of RCC and 5039 population controls, including information on socio-economic status, lifestyle habits, and diet.
- A 69-item food frequency questionnaire provided data on eating habits 2 yrs before data collection.
- Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression.
Results- Dietary intake of β-carotene and lutein/zeaxanthin was inversely associated with risk of RCC.
- ORs for the highest vs the lowest quartile were 0.74 and 0.77, respectively.
- The significant inverse association with β-carotene and lutein/zeaxanthin was more pronounced in women, and in overweight or obese subjects.
- The relation of lutein/zeaxanthin to RCC was stronger in ever smokers.
- No clear association was observed with vitamin C and E, β-cryptozanthin, and lycopene.
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