Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients
Park JT et al. - Study concludes that hyperuricaemia is common among peritoneal dialysis (PD) patients and is significantly associated with the rate of decline of residual renal function (RRF). Methods- Study was conducted to investigate:
- the prevalence of hyperuricaemia and
- the relationship between UA and RRF in PD pts
- 134 PD pts who started dialysis between Jan 2000 and Dec 2005
- Timed urine collections were performed within 1 month of PD commencement and at 6-mo intervals thereafter
- The slope of decline of RRF over time was calculated by linear regression analysis of serial urinary urea and creatinine clearances for each patient
- Biochemical and clinical data at the time of initial urine collection were considered as baseline
Results- At baseline, 32.8% of the PD pts had hyperuricaemia; majority of them were diabetic
- Hypertensive pts had a higher UA level vs normotensive pts
- The overall reduction rate of RRF in hyperuricaemic pts was higher vs normouricaemic group
- Hyperuricaemia and history of DM showed a negative correlation with the reduction rate of RRF after adjusting for:
- demographic data, comorbid conditions,
- body mass index, baseline RRF and medications
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