Familial hyperkalemia and hypertension: pathogenetic insights based on lithium clearance
Mayan H et al. - Hypercalciuria in FHHt seems to be dependent on urinary sodium. According to molecular studies, FHHt patients are presumed to have increased distal nephron sodium reabsorption, and therefore decreased proximal reabsorption of sodium, lithium and calcium. The observed decreased lithium clearance reflects probable abnormal renal handling of lithium, i.e. distal nephron lithium reabsorption. Therefore, hypercalciuria may result from proximal nephron aberration. Finally, earlier appearance of hypertension in males may be the result of sex-hormones activity. [more...]
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