Serum and urine acute kidney injury biomarkers in asphyxiated neonates
Pediatric Nephrology,  Clinical Article

Sarafidis K et al. – Serum neutrophil gelatinase–associated lipocalin (NGAL) , urine cystatin C, and urine NGAL are sensitive, early acute kidney injury (AKI) biomarkers, increasing significantly in asphyxiated neonates even in those not fulfilling AKI criteria. Their measurement on day of life 1 is predictive of post–asphyxia–AKI.

  • AKI biomarkers were measured in 13 asphyxiated neonates born at ≥36 weeks gestational age (eight with AKI and five without AKI) and 22 controls.
  • AKI was defined as serum creatinine ≥1.5 mg/dl for >24 h or rising values >0.3 mg/dl from day of life (DOL) 1.
  • Biomarkers were measured on DOL 1, 3, and 10.

  • Asphyxiated neonates had significantly higher sCysC on DOL 1 as well as sNGAL and uCysC and uNGAL (standardized to urine creatinine and absolute values) than controls at all time points.
  • Compared to controls, significantly higher sNGAL, uCysC, and uNGAL values were observed in the asphyxia-AKI and asphyxia–no AKI subgroups.
  • Regarding uKIM-1, only the absolute values were significantly higher in asphyxiated neonates (DOL 10).
  • sNGAL, uCyst, and uNGAL had a significant diagnostic performance as predictors AKI on DOL 1.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Nephrology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nephrology Articles

Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantationmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More