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Nephrology - Basic Science/Genetics News & Articles
MDLinx Nephrology is the one place you can find the most updated medical journal articles that focus on topics such as: kidney function, renal replacement therapy, immunosuppression management, clinical pharmacology, chronic kidney disease and much more. The articles found on MDLinx are thoroughly classified and expertly summarized by our team of medical editors, and then ranked to provide you optimal value for your time.
As a bonus you can check out our “must read” articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, along with clinical pearls from The Smartest Nephrologist daily quiz competition and review.
Become a member and get exclusive access to Nephrology career opportunities, e-newsletters that keep you updated with the latest medical literature, Category 1 & 2 CME credit opportunities as well as the ability to earn honoraria by participating in Market Research studies.
Your Unread Messages in Nephrology
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Articles
Latest (3) Full Text Articles (108) Focus on Transplantation441 Myoglobin-Induced Apoptosis: Two Pathways Related to Endoplasmic Reticulum Stress Therapeutic Apheresis and Dialysis, April 3, 2012
442 Comparison of C4d Detection on Erythrocytes and PTC-C4d to Histological Signs of Antibody-Mediated Rejection in Kidney Transplantation American Journal of Transplantation, April 3, 2012
443 Increased apoptosis and expression of FasL, Bax and caspase-3 in human lupus nephritis class II and IV Journal of Nephrology, April 3, 2012
444 Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy Journal of Nephrology, April 2, 2012
445 Quantitative Proteomics Identifies Vasopressin-Responsive Nuclear Proteins in Collecting Duct Cells Full Text Journal of the American Society of Nephrology, April 2, 2012
446 Enzymatic Processing of Angiotensin Peptides by Human Glomerular Endothelial Cells American Journal of Physiology: Renal Physiology, March 30, 2012
447
Endothelin 1 Activation of Endothelin A Receptor/NADPH Oxidase Pathway and Diminished Antioxidants Critically Contribute to Endothelial Progenitor Cell Reduction and Dysfunction in Salt-Sensitive Hypertension Full Text
Hypertension, March 28, 2012
Exclusive Author Commentary
448 Pleiotropic Action of Renal Cell Carcinoma-Dysregulated miRNAs on Hypoxia-Related Signaling Pathways The American Journal of Pathology, March 28, 2012
449 Identification of Gene Mutations in Autosomal Dominant Polycystic Kidney Disease through Targeted Resequencing Full Text Journal of the American Society of Nephrology, March 28, 2012
450 JNK-dependent AP-1 activation is required for aristolochic acid-induced TGF-β1 synthesis in human renal proximal epithelial cells American Journal of Physiology: Renal Physiology, March 28, 2012
451 The mechanisms of acute transplant rejection revisited Journal of Nephrology, March 28, 2012
452 Genetic studies in chronic kidney disease: basic concepts Journal of Nephrology, March 27, 2012
453 Reprogramming the kidney: a novel approach for regeneration Kidney International, March 27, 2012
454 Renal IL-17 expression in human ANCA-associated glomerulonephritis American Journal of Physiology: Renal Physiology, March 22, 2012
455 Adult patients with sporadic polycystic kidney disease: the importance of screening for mutations in the PKD1 and PKD2 genes International Urology and Nephrology, March 21, 2012
456 Evolution and Clinical Pathologic Correlations of De Novo Donor-Specific HLA Antibody Post Kidney Transplant American Journal of Transplantation, March 21, 2012
457 The enzyme 4-hydroxy-2-oxoglutarate aldolase is deficient in primary hyperoxaluria type 3 Nephrology Dialysis Transplantation, March 20, 2012
458 B-Cell Repopulation After Alemtuzumab Induction--Transient Increase in Transitional B cells and Long-Term Dominance of Naive B Cells Full Text American Journal of Transplantation, March 20, 2012
459 Intragraft Gene Expression in Positive Crossmatch Kidney Allografts: Ongoing Inflammation Mediates Chronic Antibody-Mediated Injury American Journal of Transplantation, March 15, 2012
460 Donor-Specific HLA Antibodies in a Cohort Comparing Everolimus with Cyclosporine After Kidney Transplantation American Journal of Transplantation, March 14, 2012
Clinical Pearls in Nephrology
- In patients with acute myocardial infarction, the hazard ratio (HR) for major adverse cardiac and cerebrovascular events (MACCE) was highest in patients with chronic kidney disease and anemia.
- Well-managed use of tobramycin long term is not associated with kidney failure. In a retrospective study among individuals with cystic fibrosis, the use of intravenous colistin, gentamicin, tobramycin or vancomycin did not correlate with increased BUN or creatinine after 8.5 years. Furthermore, only inhaled colistin correlated with kidney failure episodes
- Evidence by the Study of Heart and Renal Protection trial showed cardiovascular benefit and absence of special safety concerns for statin administration in chronic kidney disease; yet some experts call for additional data on renal outcomes.
Highlights in Nephrology
Risk factors for acute cardiac events in patients with community-acquired pneumonia
As published in the Journal of Infection, patients with community-acquired pneumonia (CAP) and acute cardiac events (ACEs) have a higher fatality rate (19.4%) than patients with CAP but without ACEs (6.4%). Of 3291 patients with CAP over a 15-year period, 315 had ACEs (8%; arrhythmias, n=199; congestive heart failure, n=118; myocardial infarction, n=30). Based on multivariate analysis, chronic heart disease, chronic kidney disease, tachycardia, septic shock, multilobar pneumonia, hypoalbuminemia, and pneumococcal pneumonia were associated with ACEs in patients with CAP.
Read the article summarySerum amyloid A is a sensitive biomarker for advanced renal cancer
Researchers from Martin Luther University Halle-Wittenberg (Germany) have reported that serum amyloid A (SAA) has greater sensitivity in detecting advanced renal tumors than CRP or IL-6 levels. Specifically, the sensitivities and specificities of SAA, CRP, and IL-6 for advanced renal tumors were 78%, 69%, and 44%, and 82%, 82%, and 94%, respectively. Furthermore, the SAA levels were higher in patients with advanced renal tumors than patients with localized renal tumors.
Read the article summaryNSAID-associated AKI more severe in young children
As published in the Journal of Pediatrics, NSAID-associated acute tubular necrosis and acute interstitial nephritis occurred in 21 and 6 of 1015 children with acute kidney injuries, respectively. Correct dosing of NSAIDs was confirmed in 75% of the children. Children < 5 years of age had more severe disease, more often requiring dialysis (100% vs. 0) and ICU admission (75% vs. 9%), and increased length of stay (10 d vs. 7 d).
Read the article summaryMost Popular Nephrology Articles
Last month's top read Top Articles of 20121 The Treatment of Minimal Change Disease in Adults Journal of the American Society of Nephrology, March 6, 2013 Review Article
2 Mesangial cells are responsible for orchestrating the renal podocyte injury in the context of malignant hypertension Nephrology, March 5, 2013 Review Article
3 Defining the Signals that Constitute the Nephron Progenitor Niche Journal of the American Society of Nephrology, April 19, 2013 Review Article
4 Mesenchymal stem cells and kidney repair Nephrology Dialysis Transplantation, April 1, 2013 Review Article
5 Detecting and controlling diabetic nephropathy: What do we know? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text
6 Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase Journal of the American Society of Nephrology, April 9, 2013 Review Article
7 Vimentin cleavage in end-stage renal disease is not related to apoptosis Central European Journal of Medicine, April 26, 2013 Review Article
8 The Adipose Tissue as an Endocrine Organ Seminars in Nephrology, February 20, 2013 Review Article
9 The role of the podocyte in albumin filtration Nature Reviews Nephrology, April 24, 2013 Review Article
10 Small-Molecule Screening Identifies Modulators of Aquaporin-2 Trafficking Journal of the American Society of Nephrology, April 10, 2013 Review Article
11 Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis Journal of the American Society of Nephrology, March 18, 2013 Review Article
12 Predictors of diabetic nephropathy Central European Journal of Medicine, April 23, 2013
13 Role of TNF-associated cytokines in renal tubular cell apoptosis induced by hyperoxaluria Urological Research - Urolithiasis, April 23, 2013 Review Article
14 Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1 Journal of the American Society of Nephrology, April 9, 2013 Review Article
15 Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms Journal of Clinical Pharmacy and Therapeutics, April 15, 2013
16 High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease Journal of Internal Medicine, April 25, 2013
17 Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial PLoS Medicine, April 23, 2013 Free full text
18 Nail-patella syndrome--a novel mutation in the LMX1B gene Clinical Kidney Journal, April 29, 2013 Review Article
19 Cytokines signatures in short and long-term stable renal transplanted patients Cytokine, April 12, 2013 Review Article
20 Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a full-house pattern on immunofluorescence microscopy Clinical Kidney Journal, April 22, 2013
Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantation more
Other Topics in Nephrology
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