Nephrology - Basic Science/Genetics News & Articles

MDLinx Nephrology is the one place you can find the most updated medical journal articles that focus on topics such as: kidney function, renal replacement therapy, immunosuppression management, clinical pharmacology, chronic kidney disease and much more. The articles found on MDLinx are thoroughly classified and expertly summarized by our team of medical editors, and then ranked to provide you optimal value for your time.

As a bonus you can check out our “must read” articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, along with clinical pearls from The Smartest Nephrologist daily quiz competition and review.

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Latest (2) Full Text Articles (108) Focus on Cystic Kidney Disease

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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261 Exocyst Sec10 Is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum Nephron Experimental Nephrology, February 1, 2013 Review Article

262 Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis Nephron Experimental Nephrology, February 1, 2013 Review Article

263 An Improved Method of Renal Tissue Engineering, by Combining Renal Dissociation and Reaggregation with a Low-Volume Culture Technique, Results in Development of Engineered Kidneys Complete with Loops of Henle Nephron Experimental Nephrology, February 1, 2013 Review Article

264 Fluorescence Imaging of Intracellular Calcium Signals in Intact Kidney Tissue Nephron Experimental Nephrology, February 1, 2013 Review Article

265 Podocytes Express IL-6 and Lipocalin 2/ Neutrophil Gelatinase-Associated Lipocalin in Lipopolysaccharide-Induced Acute Glomerular Injury Nephron Experimental Nephrology, February 1, 2013 Review Article

266 Activation of AMP-Activated Protein Kinase Inhibits Albumin-Induced Endoplasmic Reticulum Stress and Apoptosis through Inhibition of Reactive Oxygen Species Nephron Experimental Nephrology, February 1, 2013 Review Article

267 Aldosterone Induces Kidney Fibroblast Proliferation via Activation of Growth Factor Receptors and PI3K/MAPK Signalling Nephron Experimental Nephrology, February 1, 2013 Review Article

268 Potential Role of Serine Proteases in Modulating Renal Sodium Transport in vivo Nephron Physiology, February 1, 2013

269 Extracellular Pyrophosphate in the Kidney: How Does It Get There and What Does It Do? Nephron Physiology, February 1, 2013 Review Article

270 Response of the Renal Inner Medulla to Hypoxia: Possible Defense Mechanisms Nephron Physiology, February 1, 2013 Review Article

271 KCNJ10 Mutations Disrupt Function in Patients with EAST Syndrome Nephron Physiology, February 1, 2013 Review Article

272 An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ Nephron Physiology, February 1, 2013 Review Article

273 Expression and functional role of β3-adrenoceptors in the human ureter International Journal of Urology, January 31, 2013 Review Article

274 Role of guanine-nucleotide exchange factor epac in renal physiology and pathophysiology American Journal of Physiology: Renal Physiology, January 31, 2013 Review Article

275 Impact of HLA-G 14-bp polymorphism on acute rejection and cytomegalovirus infection in kidney transplant recipients from northwestern China Transplant Immunology, January 31, 2013 Review Article

276 LIGHT/HVEM/LTβR Interaction as a Target for the Modulation of the Allogeneic Immune Response in Transplantation American Journal of Transplantation, January 29, 2013 Review Article

277 Gene Polymorphisms of Interleukin-10 and Tumor Necrosis Factor-α Are Associated with Contrast-Induced Nephropathy American Journal of Nephrology, January 29, 2013 Review Article

278 Indoxyl Sulfate Enhances p53-TGF-β1-Smad3 Pathway in Proximal Tubular Cells American Journal of Nephrology, January 29, 2013 Review Article

279 Association of BMPR1A polymorphism, but not BMP4, with kidney size in full-term newborns Pediatric Nephrology, January 28, 2013 Review Article

280 Suppression of pro-inflammatory T-cell responses by human mesothelial cells Nephrology Dialysis Transplantation, January 28, 2013 Review Article

50 available pages First Previous 14 15 16 17 18 19 20 21 22 23 Next Last

Clinical Pearls in Nephrology

In patients with acute myocardial infarction, the hazard ratio (HR) for major adverse cardiac and cerebrovascular events (MACCE) was highest in patients with chronic kidney disease and anemia.
Well-managed use of tobramycin long term is not associated with kidney failure. In a retrospective study among individuals with cystic fibrosis, the use of intravenous colistin, gentamicin, tobramycin or vancomycin did not correlate with increased BUN or creatinine after 8.5 years. Furthermore, only inhaled colistin correlated with kidney failure episodes
Evidence by the Study of Heart and Renal Protection trial showed cardiovascular benefit and absence of special safety concerns for statin administration in chronic kidney disease; yet some experts call for additional data on renal outcomes.

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Highlights in Nephrology

Risk factors for acute cardiac events in patients with community-acquired pneumonia

As published in the Journal of Infection, patients with community-acquired pneumonia (CAP) and acute cardiac events (ACEs) have a higher fatality rate (19.4%) than patients with CAP but without ACEs (6.4%). Of 3291 patients with CAP over a 15-year period, 315 had ACEs (8%; arrhythmias, n=199; congestive heart failure, n=118; myocardial infarction, n=30). Based on multivariate analysis, chronic heart disease, chronic kidney disease, tachycardia, septic shock, multilobar pneumonia, hypoalbuminemia, and pneumococcal pneumonia were associated with ACEs in patients with CAP.

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Serum amyloid A is a sensitive biomarker for advanced renal cancer

Researchers from Martin Luther University Halle-Wittenberg (Germany) have reported that serum amyloid A (SAA) has greater sensitivity in detecting advanced renal tumors than CRP or IL-6 levels. Specifically, the sensitivities and specificities of SAA, CRP, and IL-6 for advanced renal tumors were 78%, 69%, and 44%, and 82%, 82%, and 94%, respectively. Furthermore, the SAA levels were higher in patients with advanced renal tumors than patients with localized renal tumors.

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NSAID-associated AKI more severe in young children

As published in the Journal of Pediatrics, NSAID-associated acute tubular necrosis and acute interstitial nephritis occurred in 21 and 6 of 1015 children with acute kidney injuries, respectively. Correct dosing of NSAIDs was confirmed in 75% of the children. Children < 5 years of age had more severe disease, more often requiring dialysis (100% vs. 0) and ICU admission (75% vs. 9%), and increased length of stay (10 d vs. 7 d).

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Most Popular Nephrology Articles

Last month's top read Top Articles of 2012

1 The Treatment of Minimal Change Disease in Adults Journal of the American Society of Nephrology, March 6, 2013 Review Article

2 Mesangial cells are responsible for orchestrating the renal podocyte injury in the context of malignant hypertension Nephrology, March 5, 2013 Review Article

3 Defining the Signals that Constitute the Nephron Progenitor Niche Journal of the American Society of Nephrology, April 19, 2013 Review Article

4 Mesenchymal stem cells and kidney repair Nephrology Dialysis Transplantation, April 1, 2013 Review Article

5 Detecting and controlling diabetic nephropathy: What do we know? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text

6 Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase Journal of the American Society of Nephrology, April 9, 2013 Review Article

7 Vimentin cleavage in end-stage renal disease is not related to apoptosis Central European Journal of Medicine, April 26, 2013 Review Article

8 The Adipose Tissue as an Endocrine Organ Seminars in Nephrology, February 20, 2013 Review Article

9 The role of the podocyte in albumin filtration Nature Reviews Nephrology, April 24, 2013 Review Article

10 Small-Molecule Screening Identifies Modulators of Aquaporin-2 Trafficking Journal of the American Society of Nephrology, April 10, 2013 Review Article

11 Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis Journal of the American Society of Nephrology, March 18, 2013 Review Article

12 Predictors of diabetic nephropathy Central European Journal of Medicine, April 23, 2013

13 Role of TNF-associated cytokines in renal tubular cell apoptosis induced by hyperoxaluria Urological Research - Urolithiasis, April 23, 2013 Review Article

14 Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1 Journal of the American Society of Nephrology, April 9, 2013 Review Article

15 Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms Journal of Clinical Pharmacy and Therapeutics, April 15, 2013

16 High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease Journal of Internal Medicine, April 25, 2013

17 Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial PLoS Medicine, April 23, 2013 Free full text

18 Nail-patella syndrome--a novel mutation in the LMX1B gene Clinical Kidney Journal, April 29, 2013 Review Article

19 Cytokines signatures in short and long-term stable renal transplanted patients Cytokine, April 12, 2013 Review Article

20 Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a full-house pattern on immunofluorescence microscopy Clinical Kidney Journal, April 22, 2013

Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantation more

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Nephrology - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Nephrology

Highlights in Nephrology

Risk factors for acute cardiac events in patients with community-acquired pneumonia

Serum amyloid A is a sensitive biomarker for advanced renal cancer

NSAID-associated AKI more severe in young children

Most Popular Nephrology Articles

Other Topics in Nephrology