Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake
Journal of Human Hypertension,
Rao AD et al. – Genotype status at these Serum– and glucocorticoid–inducible kinase 1 (SGK1) variants may identify individuals prone to salt–sensitive hypertension.
- Serum– and glucocorticoid–inducible kinase 1 (SGK1) has a central role in epithelial sodium channel (ENaC)–dependent Na+ transport in the distal nephron.
- Authors hypothesized that SGK1 gene variants may contribute to the effect of dietary salt intake on blood pressure (BP) in humans with hypertension, and consequentially influence rennin–angiotensin–aldosterone (RAA) system activity.
- This study population included 421 hypertensive Caucasian participants of the HyperPath group who had completed a dietary salt protocol with measurement of BP and RAA system activity.
- Three SGK1 tagging single nucleotide polymorphisms (SNPs) from the HapMap CEU population captured the genetic variation in the SGK1 region.
- Assuming an additive genetic model, two SNPs (rs2758151 and rs9402571) were associated with BP and plasma renin activity (PRA) effects of dietary salt intake.
- Major alleles were associated with higher systolic BP on high salt and decreased PRA on low salt.
- In contrast, low salt neutralized genotype differences.
- Similar, non–significant trends were observed in a normotensive population (N=152).
- Genotype was also associated with two salt–sensitive subtypes of hypertension. SGK1 genetic variants are associated with salt sensitivity of BP and PRA in human hypertension.