Survival analysis and causes of mortality in patients with lupus nephritis
Nephrology Dialysis Transplantation,

Yap DYH et al. – Lupus nephritis is associated with a 6–fold increase in mortality compared with the general population. Lupus patients who develop end–stage renal disease have a 26–fold excess in the risk of death, which is more than twice the risk associated with malignancy or cardiovascular disease in these patients.

Methods
  • The records of all lupus nephritis patients followed in a single centre during 1968–2008 were reviewed.
  • The causes of death were identified, the survival curves constructed and the standardized mortality ratios (SMRs) of potential risk factors were calculated with reference to the local general population.

Results
  • Two hundred and thirty systemic lupus erythematosus patients with history of renal involvement (predominantly Class III/IV lupus nephritis with or without membranous features) were included.
  • The follow–up was 4076.6 person–years (mean 17.7 ± 8.9 years).
  • Twenty–four patients (10.4%) died, and 85% of the deaths occurred after 10 years of follow–up.
  • The 5–, 10–, and 20–year survival rates were 98.6, 98.2 and 90.5%, respectively.
  • The leading causes of death were infection (50.0%), cardiovascular disease (20.8%) and malignancy (12.5%).
  • The renal survival rates at 5, 10 and 20 years were 99.5, 98.0 and 89.7%, respectively.
  • The SMR in patients with renal involvement, end–stage renal disease (ESRD), malignancy or cardiovascular disease was 5.9, 26.1, 12.9 and 13.6, respectively.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nephrology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nephrology Articles

1 Muscle mass and chronic kidney disease Yale School of Medicine News, November 13, 2014

2 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 Associations of sugar and artificially sweetened soda and chronic kidney disease: A systematic review and meta-analysis Nephrology, September 26, 2014    Evidence Based Medicine    Review Article

5 Tonsillectomy for IgA nephropathy: A meta-analysis American Journal of Kidney Diseases, October 29, 2014    Evidence Based Medicine

6 Dietary and pharmacologic management to prevent recurrent nephrolithiasis in adults: a clinical practice guideline from the American college of physicians Annals of Internal Medicine, November 11, 2014    Evidence Based Medicine    Clinical Article

7 Hypertension in the United States, 1999 to 2012 Circulation, November 6, 2014    Clinical Article

8 Decreased conversion of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 following cholecalciferol therapy in patients with CKD Clinical Journal of the American Society of Nephrology, November 13, 2014    Clinical Article

9 Erythropoietin and resistant hypertension in CKD Seminars in Nephrology, November 25, 2014    Clinical Article

10 Sudden cardiac death in end stage renal disease: Unlocking the mystery Full Text Journal of Nephrology, November 13, 2014    Free full text    Review Article

11 The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): A prospective randomized controlled trial Critical Care, January 13, 2014    Clinical Article

12 Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis Canadian Medical Association Journal, August 12, 2013    Evidence Based Medicine    Review Article    Clinical Article

13 Drug-induced reduction in albuminuria is associated with subsequent renoprotection: A meta-analysis Journal of the American Society of Nephrology, November 26, 2014    Evidence Based Medicine    Clinical Article

14 Effects of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on renal function in patients with stage 3 chronic kidney disease and type 2 diabetes: A Phase IIb, randomized study Full Text BMC Nephrology, November 19, 2014    Free full text    Clinical Article

15 A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography Nephrology Dialysis Transplantation, May 5, 2014    Clinical Article

16 Maintaining safety in the dialysis facility Clinical Journal of the American Society of Nephrology, November 12, 2014    Clinical Article

17 Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD Journal of the American Society of Nephrology, November 19, 2014    Clinical Article

18 Pathophysiology and treatment of resistant hypertension: The role of aldosterone and amiloride-sensitive sodium channels Seminars in Nephrology, November 24, 2014    Review Article

19 Acute kidney injury and prognosis after cardiopulmonary bypass: A meta-analysis of cohort studies American Journal of Kidney Diseases, November 7, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

20 Role of aldosterone blockade in resistant hypertension Seminars in Nephrology, October 30, 2014    Review Article

Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantationmore