Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients Full Text
Clinical Cancer Research,  Clinical Article

Griffioen AW et al. – This study describes for the first time the angiostatic response in human primary renal cancers at the tissue level upon treatment with VEGF targeted therapy. Discontinuation of treatment with tyrosine kinase inhibitors leads to accelerated angiogenesis. The results of the current study contribute important data to the ongoing discussion on the discontinuation of treatment with kinase inhibitors.

Methods
  • Phase II trials of VEGF pathway targeted therapy given prior to cytoreductive surgery were performed with metastatic RCC patients with the primary tumor in situ, to investigate the necessity of nephrectomy.
  • Primary tumor tissues were obtained and assessed for angiogenesis parameters.
  • Results were compared to similar analyses on untreated tumors.

Results
  • Sunitinib or bevacizumab pretreatment resulted in a significant reduction of microvessel density in the primary tumor.
  • Also, an increase in vascular pericyte coverage was found in sunitinib-pretreated tumors, consistent with efficient angiogenesis inhibition.
  • Expression of several key regulators of angiogenesis was suppressed in pretreated tissues, among which VEGFR-1 and -2, angiopoietin-1 and -2 and PDGF-B.
  • In addition, apoptosis in tumor and endothelial cells was induced. Interestingly, in sunitinib-pretreated tissues a dramatic increase of the number of proliferating endothelial cells was observed, which was not the case in bevacizumab-pretreated tumors.
  • A positive correlation with the interval between halting the therapy and surgery was found, suggesting a compensatory angiogenic response caused by the discontinuation of sunitinib treatment.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nephrology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nephrology Articles

1 Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study Clinical Journal of the American Society of Nephrology, May 23, 2014    Clinical Article

2 A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography Nephrology Dialysis Transplantation, May 5, 2014    Clinical Article

3 Effects of turmeric on uremic pruritus in end stage renal disease patients: A double-blind randomized clinical trial Full Text Journal of Nephrology, March 21, 2014    Free full text    Clinical Article

4 Comparison of methylprednisolone plus prednisolone with prednisolone alone as initial treatment in adult-onset minimal change disease: A retrospective cohort study Clinical Journal of the American Society of Nephrology, June 11, 2014    Clinical Article

5 Uric acid levels, kidney function, and cardiovascular mortality in US adults: National health and nutrition examination survey (NHANES) 1988-1994 and 1999-2002 American Journal of Kidney Diseases, June 4, 2014    Clinical Article

6 First-year outcomes of incident peritoneal dialysis patients in the United States American Journal of Kidney Diseases, June 13, 2014    Clinical Article

7 The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): A prospective randomized controlled trial Critical Care, January 13, 2014    Clinical Article

8 Clinical approach to renal tubular acidosis in adult patients International Journal of Clinical Practice, March 1, 2011

9 Hot bath for the treatment of chronic renal failure Renal Failure, December 9, 2013    Clinical Article

10 Chlorthalidone for poorly controlled hypertension in chronic kidney disease: An interventional pilot study American Journal of Nephrology, February 12, 2014    Clinical Article

11 Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis Canadian Medical Association Journal, August 12, 2013    Evidence Based Medicine    Review Article    Clinical Article

12 Effect of l-carnitine therapy on patients in maintenance hemodialysis: A systematic review and meta-analysis Full Text Journal of Nephrology, May 14, 2014    Free full text    Evidence Based Medicine    Review Article

13 Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months The Journal of Pediatrics, June 16, 2014    Clinical Article

14 Hypertension in hemodialysis patients treated with atenolol or lisinopril: A randomized controlled trial Nephrology Dialysis Transplantation, January 14, 2014    Clinical Article

15 Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: A randomized clinical trial Nephrology Dialysis Transplantation, November 4, 2013    Clinical Article

16 Synergism between circulating tumor necrosis factor receptor 2 and HbA1c in determining renal decline during 5–18 years of follow-up in patients with type 1 diabetes and proteinuria Diabetes Care, June 6, 2014    Clinical Article

17 Spironolactone to prevent cardiovascular events in early-stage chronic kidney disease (STOP-CKD): study protocol for a randomized controlled pilot trial Full Text Trials, May 12, 2014    Free full text    Evidence Based Medicine    Clinical Article

18 Glomerular disease: The search goes on: suPAR is not the elusive FSGS factor Nature Reviews Nephrology, June 25, 2014    Review Article

19 Remote ischemic preconditioning for prevention of acute kidney injury: A meta-analysis of randomized controlled trials American Journal of Kidney Diseases, June 23, 2014    Evidence Based Medicine    Review Article

20 Effect of hemodiafiltration or hemofiltration compared with hemodialysis on mortality and cardiovascular disease in chronic kidney failure: A systematic review and meta-analysis of randomized trials American Journal of Kidney Diseases, April 1, 2014    Evidence Based Medicine    Review Article    Clinical Article

Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantationmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close