Liu CH et al. – The authors present the case of an 8–year–old boy with Wiskott–Aldrich syndrome who developed hematuria, proteinuria, and declining renal function that did not improve with the combined use of immunosuppressive agents and angiotensin–converting–enzyme inhibitor. Renal pathology revealed IgA nephropathy. The patient underwent splenectomy for refractory thrombocytopenia. The proteinuria remitted and renal function improved after splenectomy, long–term antibiotic prophylaxis, and tapering of immunosuppressive agents.