Baseline characteristics of subjects enrolled in the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial
Nephrology Dialysis Transplantation,  Clinical Article

Chertow1 GM et al. – Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) enrolled 3883 subjects on hemodialysis with moderate to severe Secondary hyperparathyroidism (sHPT). Inclusion of subjects from multiple global regions with varying degrees of disease severity will enhance the external validity of the trial results.

Methods
  • The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial was designed to test the hypothesis that treatment with the calcimimetic agent cinacalcet compared with placebo (on a background of conventional therapy including phosphate binders +/– vitamin D sterols) reduces the risk of death or non–fatal cardiovascular events (specifically myocardial infarction, unstable angina, heart failure and peripheral arterial disease events) among patients on hemodialysis with sHPT.
  • This report describes baseline characteristics of enrolled subjects with a focus on regional variation.

Results
  • There were 3883 subjects randomized from 22 countries, including the USA, Canada, Australia, three Latin American nations, Russia and 15 European nations.
  • The burden of overt cardiovascular disease at baseline was high (e.g. myocardial infarction 12.4%, heart failure 23.3%).
  • The median plasma parathyroid hormone concentration at baseline was 692 pg/mL (10%, 90% range, 363–1694 pg/mL).
  • At baseline, 87.2% of subjects were prescribed phosphate binders and 57.5% were prescribed activated vitamin D derivatives.
  • Demographic data, comorbid conditions and baseline laboratory data varied significantly across regions.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nephrology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nephrology Articles

1 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

2 Survival of propensity matched incident peritoneal and hemodialysis patients in a United States health care system Kidney International, July 11, 2014    Clinical Article

3 Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: The PREDIAN trial Journal of the American Society of Nephrology, June 30, 2014    Clinical Article

4 A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography Nephrology Dialysis Transplantation, May 5, 2014    Clinical Article

5 Metformin in peritoneal dialysis: A pilot experience Peritoneal Dialysis International, July 8, 2014    Clinical Article

6 Evaluation of non-adherence in patients undergoing dialysis and kidney transplantation: United States transplantation practice patterns survey Transplantation Proceedings, July 21, 2014    Clinical Article

7 Clinical approach to renal tubular acidosis in adult patients International Journal of Clinical Practice, March 1, 2011

8 Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: A post hoc analysis from the RENAAL Study and the Irbesartan Diabetic Nephropathy Trial American Journal of Kidney Diseases, July 28, 2014    Clinical Article

9 Alemtuzumab-based induction treatment versus basiliximab-based induction treatment in kidney transplantation (the 3C Study): a randomised trial The Lancet, July 29, 2014    Evidence Based Medicine    Clinical Article

10 Effects of spironolactone on dialysis patients with refractory hypertension: a randomized controlled study The Journal of Clinical Hypertension, July 23, 2014    Clinical Article

11 Erythropoiesis-stimulating agent use among non-dialysis-dependent CKD patients before and after the trial to reduce cardiovascular events with Aranesp therapy (TREAT) using a large US health plan database American Journal of Kidney Diseases, July 10, 2014    Clinical Article
Exclusive Author Commentary

12 Vancomycin-resistant enterococci colonization among dialysis patients: A meta-analysis of prevalence, risk factors, and significance American Journal of Kidney Diseases, July 18, 2014    Review Article

13 The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): A prospective randomized controlled trial Critical Care, January 13, 2014    Clinical Article

14 Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis Canadian Medical Association Journal, August 12, 2013    Evidence Based Medicine    Review Article    Clinical Article

15 Serum metabolomic profiling and incident CKD among African Americans Clinical Journal of the American Society of Nephrology, July 14, 2014    Clinical Article

16 Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study Clinical Journal of the American Society of Nephrology, May 23, 2014    Clinical Article

17 The relationship of cystatin-C change and the prevalence of death or dialysis need after acute kidney injury: A meta-analysis Nephrology, July 7, 2014    Evidence Based Medicine

18 Aldosterone blockade in chronic kidney disease Seminars in Nephrology, July 14, 2014    Clinical Article

19 Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: A randomized clinical trial Nephrology Dialysis Transplantation, November 4, 2013    Clinical Article

20 Cardiac and kidney markers for cardiovascular prediction in individuals with chronic kidney disease Arteriosclerosis, Thrombosis, and Vascular Biology, July 22, 2014    Clinical Article

Indexed Journals in Nephrology: Kidney International, Hemodialysis International, Nephrology Dialysis Transplantationmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close