Outcomes of patients with end-stage renal disease (ESRD) under chronic hemodialysis requiring continuous renal replacement therapy (CRRT) and patients without ESRD in acute kidney injury requiring CRRT: A single-center study
Hemodialysis International,  Clinical Article

Jung YS et al. – The survival rates of non–end–stage renal disease (ESRD) and ESRD patients requiring continuous renal replacement therapy did not differ; ESRD with conventional hemodialysis patients may be not a significant predictor of mortality.

Methods
  • The authors evaluated adults (>18 years) requiring CRRT who were treated in the intensive care unit (ICU) at Kosin University Gospel Hospital from January 1, 2009 to December 31, 2010.
  • A total of 100 (24 ESRD, 76 non-ESRD) patients underwent CRRT during the study period.
  • Patients were divided into two major groups: patients with ESRD requiring chronic dialysis and patients without ESRD (non-ESRD) with AKI.
  • The authors compared the survival of conventional HD patients requiring CRRT with the survival of non- ESRD patients in AKI requiring CRRT.

Results
  • For non-ESRD patients, the 90-day survival rate was 41.6%.
  • For ESRD patients, the 90-day survival rate was 55.3%.
  • Multivariate Cox proportional hazards analyses demonstrated that conventional HD was not a significant predictor of mortality (hazard ratio [HR]: 0.334, 95% confidence interval [CI]: 0.063-1.763, P = 0.196), after adjustment for age, gender, presence of sepsis, APACHE score, use of vasoactive drugs, number of organ failures, ultrafiltration rate, and arterial pH.

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