Fagundes C et al. – A liver transplant is the preferred treatment for Hepatorenal syndrome (HRS). Pharmacologic treatment with vasoconstrictors to reverse splanchnic vasodilation, together with albumin, is effective in 40%–50% of patients with type 1 HRS and improves survival. The drug of choice is the vasopressin analogue terlipressin. Renal replacement therapy should not be used as first–line therapy.